News from Biolin Scientific
Posted on February 23, 2017
Action potentials are induced in both HL-1 mouse atrial cardiomyocytes and Axiogenesis Cor.4U iPS cell-derived cardiomyocytes.
Posted on January 30, 2017
For a long time, screening assays on CaV1.2 have been challenged by the tendency of CaV1.2 cell lines to exhibit declining current levels in the course of the experiment. Here we report a robust assay with high success rates and reliable pharmacology.
• Success rates of 91% for Ca2+ currents and 98% for Ba2+ were achieved
• Stable currents with as low as 0.6 ± 1.8% rundown per minute
• Reference pharmacology in accordance with literature values
• Use-dependent and use-independent mode of action distinguished with different voltage protocols
Posted on January 13, 2017
Come join the global Biolin Scientific team. Right now we are looking to fill positions in Finland and Sweden.
Posted on December 7, 2016
AddLife acquires Biolin Scientific AB – world leading instruments for material analysis at the nanoscale.
TMEM16A – a robust high throughput e-phys assay for a key ion channel involved in cancer and cystic fibrosis
Posted on November 28, 2016
New application report on TMEM16A on Qube with precisely clamped internal Ca2+ and high seal resistances throughout the entire experiment.
Posted on November 15, 2016
Charles River recently expanded its ion channel capabilities through the addition of a Sophion Qube 384-well automated patch-clamp platform with stacker
Posted on November 3, 2016
We are pleased to share with you some of the video presentations from ICMS 2016 in Cambridge this summer.
Posted on October 13, 2016
Biolin Scientific announces today that the company has launched a new, improved version of its QCM-D analysis software.
Posted on September 13, 2016
Biolin Scientific announce today that study results for a new scientific method to evaluate and rank the cleaning ability of new detergent formulations have been published in the journal Tenside Surfactants Detergents (TSD).
Biolin Scientific partners with L.A.B. Analytical to expand analytical instrument business in Scandinavia
Posted on August 22, 2016
Biolin Scientific partners with L.A.B. Analytical. Biolin Scientific has signed an agreement with L.A.B. Analytical, a specialist laboratory appliances provider, to distribute Biolin Scientific’s state-of the-art surface analysis instruments in Sweden, Denmark, Norway and Iceland.
Posted on May 30, 2016
In electrophysiology literature values for IC50 can range from a few nM to several hundred µM for a specific compound. Variations are caused by many parameters such as the cell line itself, the growth conditions, measurement platform, voltage protocol, solutions etc.
Posted on May 25, 2016
The flexibility of Qube allows almost indefinite adaptation to user needs. For example, one might want to exchange the intracellular solution (IC) during an experiment. To illustrate this we changed all of the IC during hERG recordings and replenished half the columns with the original solution and the other half with an IC devoid of K+. The left panel shows the hERG current before the IC exchange. The right panel shows the preservation respectively abolishment of the hERG current in alternating columns as a result of exchanging the IC.
Posted on May 9, 2016
Biolin Scientific has signed an agreement with DKSH, a leading market expansion services provider with focus on Asia, to market Biolin Scientific’s state-of-the-art tensiometers in China.
First ever giga-seal based high throughput screening of almost 200,000 compounds have been published
Posted on April 1, 2016
The first ever giga-seal based high throughput screening of almost 200,000 compounds have been published using Qube automated patch clamp system.
Posted on March 16, 2016
Today Biolin Scientific announces a new initiative for Q-SenseTM where the entire product line will be upgraded.
Posted on February 1, 2016
Biolin Scientific is looking for a summer trainee for the Analytical Instrument business unit based in Espoo, Finland.
Posted on January 25, 2016
“Quartz Crystal Microbalance – The Principle and Application” is a new book authored by Prof. Guangzhao Zhang and Prof. Guangming Liu published by Sciencepress China.
Posted on December 16, 2015
This year we choose to give a Christmas gift to UNHCR.
With this donation, UNHCR can help keep refugees warm and safe this winter.
Posted on November 13, 2015
Biolin Scientific is looking for a Global Product Manager for the Drug Discovery business unit (Sophion brand) based in Ballerup, Copenhagen.
Posted on November 5, 2015
In this white paper we will take an in-depth look at the principles underlying the 3D Topography Module method, resulting roughness parameters, and also the Wenzel theory used for roughness corrected contact angles. We will also highlight applications and samples that are feasible for this method.
Posted on September 30, 2015
Last week Application Specialist Jennie Ringberg taught Quartz Crystal Microbalance with Dissipation monitoring, QCM-D, at NFC Summer School in Espoo, Finland.
Posted on August 26, 2015
We recently had the opportunity to interview Abraham Joy, Dept of Polymer Science at the University of Akron, about his research within biomaterials- and biomedical applications.
Posted on June 22, 2015
Biolin Scientific Holding AB has appointed Thais Johansen as VP of the Drug Discovery business unit (Sophion), where he replaces Morten Sunesen.
Posted on May 26, 2015
Update v2.5 is now available for OneAttension software. The update contains several improvements such as enhancement to dynamic contact angle analysis with Theta optical tensiometers and several usability updates.
Posted on May 21, 2015
Please read this really interesting article by Dr. Kohei Sawada involving CiPA assays on QPatch.
Posted on May 18, 2015
Check out BaAMPs, the first database dedicated to antimicrobial peptides (AMPs) specifically tested against microbial biofilms.
Posted on May 6, 2015
This week, some of the most prominent researchers within materials-, energy-, nano- and life science meet at Chalmers in Gothenburg, Sweden for a 5 day workshop symposium called Amazing Week at Chalmers
Posted on March 25, 2015
Biolin Scientific is pleased to announce the hiring of Duncan Jarman for the role of Sales Manager EMEA, supporting the Sophion brand of ion channel screening instrumentation
Posted on March 19, 2015
The paper describes the development of a reference biosensor surface, based upon a binary mixture of oligo-ethylene glycol thiols, one of which has biotin at the terminus, adsorbed onto gold as self-assembled monolayers (SAMs).
Posted on March 10, 2015
Biolin Scientific today announces the launch of the Attension High Pressure Chamber that enables surface analysis at experimental conditions mimicking oil reservoirs.
Posted on March 5, 2015
Biolin Scientific is seeking a self-motivated Territory Manager to drive sales of its analytical instrument brands; including Q-SENSE brand, the world leader in the Quartz Crystal Microbalance Technology; ATTENSION brand, the best value for measuring contact angles and surface free energy; and KSV-NIMA brands, fine instrumentation for measuring monolayer films
Posted on March 4, 2015
High-Throughput Screen of GluK1 Receptor Identifies Selective Inhibitors with a Variety of Kinetic Profiles Using Fluorescence and Electrophysiology Assays
Posted on February 20, 2015
Earlier this week we ran a live webinar on wettability measurements in quality control of industrial processes. If you didn’t get the chance to see it, take the opportunity to see the recorded webinar now!
Posted on February 5, 2015
Stockholm and Munich February 5, 2015 – Biolin Scientific Holding AB, Sweden and Nanion Technologies GmbH, Germany today announce that the parties have entered into a licensing agreement. Biolin Scientific has agreed to grant a non-exclusive license for the key patent related to performing multi-hole, high-throughput ion channel screening to Nanion Technologies in exchange for an undisclosed license fee. The non-exclusive license will provide Nanion Technologies with freedom to operate for the entire life time of the patents.
Posted on February 3, 2015
Biolin Scientific launches new software that optimizes contact angle measurements for industrial quality control.
Posted on January 27, 2015
Biolin Scientific has acquired a patent from Xention Ltd. that protects multi-hole high-throughput patch clamp analysis. This acquisition strengthens the position of the Sophion brand as the leader in high-throughput ion channel screening using patch clamp technology.
Posted on December 30, 2014
A study at the Institute of Food Research, Norwich UK, has investigated how common chemicals found in toothpaste (Sodium dodecyl sulphate, SDS, and sodium tripolyphosphate, STP) can alter the protective film of the saliva.
Posted on December 9, 2014
All electrical networks depend on the quality of the transformers. Functional failure means maintenance, costly repairs and production down time. The insulating transformer oil in a power transformer says a lot about the transformers condition.
Posted on December 5, 2014
Dublin City University published a new paper on selective inhibitors of neuronal Kv1 channels.
Selective inhibitors of voltage-activated K+ channels are needed for the treatment of multiple sclerosis. In this work it was discovered that porphyrins bearing 2–4 carbon alkyl ammonium side chains predominantly blocked the Kv1.1 current whilst Kv1.2 was susceptible to a porphyrin bearing polyamine side chains.
Posted on November 17, 2014
Want to learn how to use QCM-D for protein-protein-and nucleic acid/protein interaction studies?
Posted on November 13, 2014
Are you looking for a measurement technique that brings a new dimension to what can be analyzed in your lab?
Posted on October 7, 2014
The KSV NIMA Application Overview describes how the Langmuir-Blodgett (LB) technology is used to fabricate highly organized mono- and multi-layer nanoparticle films.
Posted on September 10, 2014
Marine mussels are unbeatable when it comes to underwater adhesive strategies. They can attach to virtually all inorganic and organic surfaces, tenaciously sustaining their bonds even in saltwater under turbulent wave-swept conditions.
Posted on August 15, 2014
Here is a new application note from Q-Sense on Surfactant-Surface Interactions. This Application Note illustrates how the QCM-D technology can be used to study surfactant interactions with surfaces in real time with nanoscale sensitivity.
Posted on August 6, 2014
Q-Sense, together with Biolin Scientific, has recently co-published a new study titled “Monitoring N3 Dye Adsorption and Desorption on TiO2 Surfaces: A Combined QCM-D and XPS Study”
Posted on August 5, 2014
KSV NIMA is excited to introduce a new Langmuir-Blodgett characterization kit
Posted on August 4, 2014
Biolin Scientific and Q-Sense were sponsors of the recently held 2014 Workshop on Protein Aggregation and Immunogenicity in Breckenridge, Colorado.
Posted on July 30, 2014
Q-Sense offers the widest range of QCM sensor coatings and substrates including metals, metal oxides, polymers, biological sensors and other materials. See below for more details.
Posted on July 29, 2014
The 15th International Conference on Organized Molecular Films (otherwise known as LB-15) was recently held on Jeju Island in Korea. General topics include studies on Langmuir and Langmuir-Blodgett films, Self-Assembled Monolayers and other nano-scale structures.
Posted on July 25, 2014
A recent paper in Nature Communications elucidates the pathway by which gold nanoparticles spontaneously insert into lipid bilayers. Nature Communications 5, Article number: 4482 doi:10.1038/ncomms5482
Posted on July 17, 2014
A top London-based university has purchased a Q-Sense Omega Auto that will be used for materials characterization. This installation will be a reference site for the Omega Auto and will help facilitate demonstrations, workshops and other events within the UK.
Posted on July 11, 2014
KSV NIMA has just released a new application note titled: Nanostrand formation of block copolymers at the air/water interface.
Posted on June 18, 2014
The 15th annual International Conference on Petroleum Phase Behavior and Fouling just finished up in Houston, TX.
Posted on June 17, 2014
Biolin Scientific Inc. recently held a hands-on training course for the Langmuir and Langmuir-Blodgett technologies and instrumentation in the Linthicum Heights, MD laboratory.
Posted on June 16, 2014
Learn more about contact angle, surface tension and powder wettability measurements! Watch the OneAttension software webinars that covers how to perform these and many more measurements. You will also see how the new 3D Topography Module is utilized. You find the webinars in the Software section under Attension Services. Go straight to the webinars.
Posted on June 4, 2014
We hope you haven’t missed that we recently launched a new Q-Sense sensor? This functionalized sensor complements our existing range of bio-surfaces; Q-Sense Biotin Sensor and Q-Sense His-tag Capturing Sensor. With the Amine coupling sensor added to our product range, we now offer an expanded set of functionalities, targeting different protein immobilization strategies which enables additional applications with Q-Sense QCM-D instruments.
Posted on May 26, 2014
Check out 10 of the latest and most influential publications with KSV NIMA Langmuir-Blodgett Troughs in graphene and nanoparticle research! We have gathered them for you with a brief summary and if you want to read more, click on the title.
Posted on May 19, 2014
Sophion Bioscience (sophion.com), part of Biolin Scientific, has received its first purchase orders for its new high throughput screening platform from leading pharma companies
Posted on May 14, 2014
Biolin Scientificグループの一翼を担うSophion Bioscience A/S (sophion.com)は、大手製薬会社におけるハイスループットスクリーニング用のプラットフォームとして、このほど新規の案件を受注しました。Sophion Qube ™は、細胞膜に発現するイオンチャネルに対する新薬候補化合物の作用を直接測定することができます。比類のない高品質記録とハイスループットの組み合わせにより、Sophion Qubeはイオンチャネル創薬の初期段階における生産性を飛躍的に向上させます。
Posted on March 7, 2014
Since 1995 the Danish financial newspaper Børsen has identified the Danish growth elite, and each year nominated a number of growth companies that fulfill the criteria.
Posted on March 7, 2014
New Application Note available on the characterization of polymer layer swelling and collapse by the QCM-D technology.
Posted on February 12, 2014
The Nobel Prize in Physiology or Medicine 2013 was awarded jointly to James E. Rothman, Randy W. Schekman and Thomas C. Südhof “for their discoveries of machinery regulating vesicle traffic, a major transport system in our cells”.
Posted on February 10, 2014
The KSV NIMA Brewster Angle Microscopes represents the latest in BAM instrumentation allowing high resolution and fully focused real-time imaging of monolayers.
Posted on July 23, 2013
The recent Think Tank Meeting held at the FDA “Rechanneling the Current Cardiac Safety Paradigm” (23rd of July, 2013) concluded: A robust and biologically relevant assessment of potential clinical arrhythmia should include assessment of multiple ion channels and the current s7b minimal standard does not reflect this.
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