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    A DNA Nanostructure-based Biomolecular Probe Carrier Platform for Electrochemical Biosensing

    Year: 2010

    Journal: Advanced Materials Volume 22, Issue 42, pages 4754–4758, 20111024

    Authors: Pei H, Lu N, Wen Y, Song S, Liu Y, Yan H, Fan C.

    Last authors: Chunhai Fan

    Organizations: Laboratory of Physical Biology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, 201800 (P. R. China) Department of Chemistry and Biochemistry & The Biodesign Institute, Arizona State University, Tempe, AZ (USA)

    Country: China, US, USA, United States of America

    A 3D DNA nanostructure-based sensor platform for DNA detection has been developed. This strategy provides significantly enhanced spatial positioning range and accessibility of the probes on a surface over previously reported DNA sensing architectures. The use of this versatile DNA nanostructure-based detection platform leads to highly sensitive and selective DNA detection in biological fluids and greatly enhanced sequence specificity for SNP typing.