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    Antibacterial Capability, Physicochemical Properties, and Biocompatibility of nTiO(2) Incorporated Polymeric Scaffolds

    Year: 2018

    Journal: Polymers, Volume 10, MAR

    Authors: Shuai, Cijun; Shuai, Chenying; Feng, Pei; Gao, Chengde; Peng, Shuping; Yang, Youwen

    Organizations: Natural Science Foundation of China [51575537, 81572577, 51705540]; National Natural Science Foundation of China [81428018]; Hunan Provincial Natural Science Foundation of China [14JJ1006, 2016JJ1027]; Project of Innovation-driven Plan of Central South University [2015CXS008, 2016CX023]; Open-End Fund for the Valuable and Precision Instruments of Central South University; State Key Laboratory of Solidification Processing at NWPU [SKESP201605]; State Key Laboratory for Powder Metallurgy; Fundamental Research Funds for the Central Universities of Central South University [2017zzts406]; National Postdoctoral Program for Innovative Talents [BX201700291]

    Keywords: nano titanium dioxide; antibacterial capability; cellular attachment; polymeric scaffolds

    Postoperative infection is a common risk which brings about failure in bone transplantation. In this study, nano titanium dioxide (nTiO(2)) was incorporated into Polyetheretherketone/polyglycolicacid (PEEK/PGA) blends to construct antibacterial scaffolds via selective laser sintering. Antibacterial capability was assessed using Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). The results demonstrated that the scaffolds with nTiO(2) presented an effective antibacterial activity, which might be attributed to that nTiO(2) would do the mechanical and oxidative damage to bacteria by occurring contact actions and generating reactive oxygen species (ROS), and thus killed bacteria from structure and function. Moreover, nTiO(2) could enhance the tensile strength and modulus of scaffolds due to the reinforcing effect and its uniform disperse. And the cell culture experiments showed that nTiO(2) stimulated cellular attachment and proliferation. Besides, it also elevated the hydrophily and thermal stability of scaffolds. These results suggested that the polymeric scaffolds incorporated nTiO(2) had potential application in bone tissue engineering.
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