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    Biodegradable Polymer with Hydrolysis-Induced Zwitterions for Antibiofouling

    Year: 2018

    Journal: ACS Appl. Mater. Interfaces, Volume 10, APR 4, page 11213–11220

    Authors: Xie, Qngyi; Xie, Qianni; Pan, Jiansen; Ma, Chunfeng; Zhang, Guangzhao

    Organizations: National Natural Science Foundation of China [51673074, 51573061]; Fundamental Research Funds for the Central Universities

    Keywords: protein resistance; antifouling; hydrolysis; degradation; radical ring-opening copolymerization

    Persistent protein resistance is critical for marine antibiofouling. We have prepared copolymer of 2-methylene-1,3-dioxepane (MDO), tertiary carboxybetaine ester (TCB), and 7-methacryloyloxy-4-methylcoumarin (MAMC) via radical ring-opening polymerization, where MDO, TCB, and MAMC make the polymer degradable, protein resistible, and photo-cross-linkable, respectively. Our study shows that the polymer can well adhere to the substrate with controlled degradation and water adsorption rate in artificial seawater (ASW). Particularly, the polymer film can generate zwitterions via surface hydrolysis in ASW. Quartz crystal microbalance with dissipation measurements reveal that such hydrolysis-induced zwitterionic surface can effectively resist nonspecific protein adsorption. Moreover, the surface can inhibit the adhesion of marine bacteria Pseudomonas sp. and Vibrio alginolyticus as well as clinical bacterium Escherichia coli.
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