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    Controlled Assembly and Release of Retinoic Acid Based on the Layer-by-Layer Method

    Year: 2013

    Journal: Langmuir, 2013, 29 (8), pp 2708–2712, 20130403

    Authors: Yueyue Chen 1, Guanghong Zeng 2, Fei Pan 1, Junbo Wang 3, and Lifeng Chi *1

    Last authors: Lifeng Chi

    Organizations: 1 Physikalisches Institut and Center for Nanotechnology (CeNTech), Universität Münster, 48149 Münster, Germany 2 Key Lab of Organic Optoelectronics & Molecular Engineering, Department of Chemistry, Tsinghua University, Beijing 100084, People’s Republic of China 3 Institute of Electronics, Chinese Academy of Sciences, Beijing 100190, People’s Republic of China

    Country: china, germany

    All-trans retinoic acid (RA) has been proved to play important roles in regulating cell growth in various types of cells. Yet most experiments were performed by adding RA in solution previously. In this Article, we focus on the incorporation of RA, as a negatively charged moiety, into layered polyelectrolyte films on surfaces by means of layer-by-layer (LbL) deposition, followed by adding of capping layers to regulate the release of RA from the films. The incorporated RA was designed to release over 5 days in buffer solution. The assembly and release of RA were verified by UV and QCM results. The controlled release of RA from multilayer films can serve as a model system to study the influence of small molecules on cell growth.