Year: 2014
Journal: Chem. Commun., 2014,50, 13070-13072, 20141010
Authors: Heike M. A. Ehmann,*Tamilselvan Mohan,Maria Koshanskaya,Sylvia Scheicher,Doris Breitwieser,Volker Ribitsch,Karin Stana-Kleinschek Stefan Spirk *
Last authors: Stefan Spirk
Organizations: a Institute for Chemistry and Technology of Materials, Graz University of Technology, Stremayrgasse 9, 8010 Graz, Austria b Institute for Chemistry, University of Graz, Heinrichstrasse 24, 8010 Graz, Austria c Joanneum Research Materials, Institute for Surface Technologies and Photonics, Franz-Pichlerstrasse 30, 8160 Weiz, Austria d Institute for the Engineering and Design of Materials, University of Maribor, Smetanova Ulica 17, 2000 Maribor, Slovenia
Country: Austria, Slovenia
The anticoagulant activity of surfaces decorated with cellulose nanocrystals (CNCs) prepared viasulfuric acid hydrolysis, is explored. Such surfaces bear a high amount of negatively charged sulfate groups, which mimic the naturally occurring anticoagulant heparin in terms of charge density. It is demonstrated that CNC decorated surfaces significantly enhance the coagulation times of blood plasma and whole blood as proven by QCM-D and simple clotting tests.
