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    DPPC monolayer response to non-spanning cobalt-cage metallosurfactants: Electrostatic complex formation

    Year: 2018

    Journal: Chem. Phys. Lipids, Volume 213, JUL, page 1–12

    Authors: Lalgee, Lorale J.; Cox, Leonette; Fairman, Richard A.; Grierson, Lebert

    Organizations: University of the West Indies, St. Augustine

    Keywords: DPPC Langmuir monolayers; Langmuir-Blodgett; Cobalt-cage complexes; Metallosurfactant; Atomic force microscopy

    A novel series of amphiphilic cobalt-cage derivatives (ACCD), bearing a diaza-crown bridge and varying alkyl chains, facilitate ion transport across biomembrane models via self-aggregation. In this study, compression isotherm analyses and atomic force microscopy (AFM) were used to assess the interactions of these amphiphiles with Langmuir monolayers of dipalmitoylphosphatidylcholine (DPPC) in order to elucidate electrostatic and steric contributions to ion transport. The stability and compressibility of DPPC monolayers are disrupted by ACCD molecules with short (C12) alkyl chains. These top-heavy amphiphiles (large cone angles) create voids at the interface of the hydrophobic/aqueous layer leading to monolayer expansion and packing efficiency of the aliphatic chains is disrupted. Long-tailed analogues (C16, C18) are cohesively integrated into DPPC monolayers due to their smaller cone angles at the interfacial region and increased hydrocarbon compatibility in the hydrophobic region. Thermodynamic data indicate the formation of electrostatic complexes between DPPC and longer-tailed amphiphiles consistent with AFM observations of aggregate structures at the corresponding concentrations.
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