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    Fibrous polymeric buccal film formulation, engineering and bio-interface assessment

    Year: 2017

    Journal: Eur. Polym. J., Volume 97, DEC, page 147–157

    Authors: Nazari, Kazem; Kontogiannidou, Eleni; Ahmad, Rita Haj; Andreadis, Dimitrios; Rasekh, Manoochehr; Bouropoulos, Nikolaos; van Der Merwe, Susanna M.; Chang, Ming-Wei; Fatouros, Dimitrios G.; Ahmad, Zeeshan

    Keywords: Electrospinning; Buccal delivery; In vitro; Ex-vivo; Indomethacin; Bio-interface

    Polymer based dosages form the mainstay of drug delivery systems either as simple matrix carrier materials or active release behavior modulating agents. In addition, several techniques have been developed further to deliver novel polymeric structures. One such method is electrospinning (ES); a maturing process which is operational at the ambient environment and enables drug loading (in molecularly dispersed form) directly into a fibrous polymer matrix system. Since there is an impending need to address healthcare challenges arising from an increase in the aging population (requiring enhanced treatments), the ES method was used to develop fibrous polymer composite-indomethacin (INDO) films for potential use in the buccal region. Films were assessed for their inter-facial behavior at bio-interfaces (in-vitro and ex-vivo). Polymeric excipients possessing an established profile for commercial dosage form development were selected. Fibrous films (all fibre components < 400 nm) were characterised using DSC, TGA, FTIR, Raman and XRD. DSC and XRD demonstrated INDO change from crystalline to amorphous state. FTIR and Raman data suggest INDO, PVP and co-polymers (Methocel (TM) E5, Methocel (TM) E15 and Tween (R) 80) were integrated in stable fashion into filamentous structures via ES. Variable INDO release behavior from several matrices was observed suggesting a potential route to tailor drug release based on polymeric excipient use and ratio. Furthermore, permeation studies using a porcine buccal model demonstrated sustained permeation once dosages are attached to the buccal mucosa. The insoluble nature of cellulose excipients were used to promote sustained release while the use of Tween (R) 80 surfactant was used to enhance permeation of INDO through polymer interaction with excised tissue. Finally, histology studies indicate polymer excipient selection impacts the bio-interface. In summary, a facile approach to formulate, encapsulate and engineer fibrous polymeric buccal films (on demand) is shown. The method enables drug dispersion directly within the composite polymeric system, which has a clear impact on drug release, in-vitro and ex-vivo bio-interaction.
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