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    Functionalizable self-assembled trichlorosilyl-based monolayer for application in biosensor technology

    Year: 2017

    Journal: Appl. Surf. Sci., Volume 414, AUG 31, page 435–441

    Authors: De la Franier, Brian; Jankowski, Alexander; Thompson, Michael

    Organizations: Natural Sciences and Engineering Research Council of Canada

    Keywords: SAM; Trichlorosilane; Linker; Acid chloride; Monolayer; Biosensor

    This paper describes the design and synthesis of 3-(3-(trichlorosilyl)propoxy)propanoyl chloride (MEG-Cl), a compound capable of forming functionalizable monolayers on hydroxylated surfaces. The compound was synthesized in high purity, as suggested by nuclear magnetic resonance analysis, and in moderate overall yield. Contact angle measurement and X-ray photoelectron spectroscopy confirm the binding of MEG-Cl to an amorphous glass substrate and the further modification of the monolayer with a nickel (II)-binding ligand for the purpose of binding polyhistidine-tagged proteins. The compound will be useful in biosensing applications due to its ability to be easily modified with any number of nucleophilic functional groups subsequent to substrate monolayer formation. (C) 2017 Elsevier B.V. All rights reserved.
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