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    He/O-2 Atmospheric Pressure Plasma Jet Treatments of PCL Scaffolds for Tissue Engineering and Regenerative Medicine

    Year: 2015

    Journal: PLASMA PROCESSES AND POLYMERS, Vol. 12, p 1451-1458, 20170208

    Authors: Trizio, Ilaria; Intranuovo, Francesca; Gristina, Roberto; Dilecce, Giorgio; Favia, Pietro

    Organizations: Univ Bari, Dept Chem, Via Orabona 4, I-70126 Bari, Italy; CNR, NANOTEC Inst, Via Orabona 4, I-70126 Bari, Italy

    The goal of this work was to achieve proper chemical modification of poly-e-caprolactone porous scaffolds by means of He/O-2 Atmospheric Pressure Plasma-Jet treatments with the aim of improving their affinity with cells. The surface chemical composition and wettability of plasma processed scaffolds was characterized, their cytocompatibility was tested with human Saos-2 osteoblasts cells. Plasma-grafted polar groups were found to improve the hydrophilicity of the scaffolds, which resulted in better clusterization and cytoskeleton morphology of cells cultured on them.