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    Homogeneous synthesis of linoleic acid-grafted chitosan oligosaccharide in ionic liquid and its self-assembly performance in aqueous solution

    Year: 2015

    Journal: JOURNAL OF APPLIED POLYMER SCIENCE, Vol. 132, p -, 20170208

    Authors: Liu, Yuanyuan; Huang, Yan; Boamah, Peter-Osei; Cao, Li; Zhang, Qi; Lu, Zhengrong; Li, Huaming

    Organizations: Jiangsu Univ, Sch Chem & Chem Engn, Zhenjiang 212013, Jiangsu, Peoples R China; Hainan Univ, Hainan Prov Key Lab Fine Chem, Haikou 570228, Hainan, Peoples R China; Case Western Reserve Univ, Dept Biomed Engn, Cleveland, OH 44106 USA

    A water-soluble amphiphilic derivative of chitosan oligosaccharide (COS) modified with linoleic acid (LA)-grafted COS (LCOS) has been synthesized in the ionic liquid 1-butyl-3-methylimidazolium acetate ([BMIM]Ac). The effects of the ionic liquid on the degree of substitution (DS), surface activity, and self-assembly behavior of LCOS have been investigated. The results showed that the ionic liquid homogeneous system led to a relatively higher DS compared with the product synthesized in a traditional organic solvent. Furthermore, the LCOS synthesized in the ionic liquid had better surface activity (cmc=1.1 x 10(-4) g.mL(-1)), and could also self-assemble into nanomicelles with better-defined spherical shape and a narrower particle size distribution (30-40 nm) in aqueous solution. These results suggest that an effective and environmentally friendly synthesis method for COS derivatives has been established and, moreover, the obtained LCOS micelles meet the basic requirements for use as an improved drug transduction vector. (c) 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 41727.