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    In vitro antimicrobial activity of solution blow spun poly(lactic acid)/polyvinylpyrrolidone nanofibers loaded with Copaiba (Copaifera sp.) oil

    Year: 2015

    Journal: MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, Vol. 48, p 372-377, 20170208

    Authors: Bonan, Roberta F.; Bonan, Paulo R. F.; Batista, Andre U. D.; Sampaio, Fabio C.; Albuquerque, Allan J. R.; Moraes, Maria C. B.; Mattoso, Luiz H. C.; Glenn, Gregory M.; Medeiros, Eliton S.; Oliveira, Juliano E.

    Organizations: Univ Fed Paraiba, Dept Engn Mat DEMAT, BR-58051900 Joao Pessoa, Paraiba, Brazil; Univ Fed Paraiba, Ctr Ciancias & Saude, BR-58051900 Joao Pessoa, Paraiba, Brazil; Embrapa Recursos Genet & Biotecnol, Lab Semioquim, ASA NORTE, BR-70770900 Brasilia, DF, Brazil; Embrapa Instrumentacao Agr CNPDIA, Lab Nacl Nanotecnol & Agronegacio, BR-1356097 Sao Carlos, SP, Brazil; USDA, Western Reg Res Ctr, Albany, CA 94710 USA; Univ Fed Lavras, Dept Engn, BR-37200000 Lavras, MG, Brazil

    In this study poly(lactic add) (PLA) and polyvinylpyrrolidone (PVP) micro- and nanofiber mats loaded with Copaiba (Copaifera sp.) oil were produced by solution blow spinning (SBS). The Copaiba (Copaifera sp.) oil was characterized by gas chromatography (GC). Neat PLA and four PLA/PVP blends containing 20% (wt.%) oil were spun and characterized by scanning electron microscopy (SEM) and by studying the surface contact angle, in vitro release rate, and antimicrobial activity. All compositions evaluated were able to produce continuous and smooth fibers by SBS. The addition of PVP increased fiber diameter, and decreased the surface contact angle. GC analysis demonstrated that the main component of the Copaiba oil was beta-caryophyllene, a known antimicrobial agent. In vitro release tests of Copaiba oil volatiles demonstrated a higher release rate in fibers containing PVP. Fiber mats made from blends containing higher amounts of PVP had greater antimicrobial action against Staphylococcus aureus. The results confirm the potential of the fiber mats for use in controlled drug release and could lead to promising applications in the biomedical field. (C) 2014 Elsevier B.V. All rights reserved.