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    Langmuir Mono layers and Thin Films of Amphifilic Thiacalix[4]arenes. Properties and Matrix for the Immobilization of Cytochrome c

    Year: 2014

    Journal: LANGMUIR, Vol. 30, p 15153-15161, 20150722

    Authors: Solovieva, Svetlana E.; Safiullin, Roman A.; Kochetkov, Evgeni N.; Melnikova, Nina B.; Kadirov, Marsil K.; Popova, Elena V.; Antipin, Igor S.; Konovalov, Alexander I.

    Organizations: Russian Acad Sci, AE Arbuzov Inst Organ & Phys Chem, Kazan 420088, Russia; Nizhny Novgorod State Med Acad, Nizhnii Novgorod 603600, Russia; Kazan Fed Univ, Kazan 420008, Russia

    Formation and properties of Langmuir films of thiacalix[4]arene (TCA) derivatives containing N-donor groups on the lower rim (Y=O(CH2)(3)CN; OCH2CN; NH2; OCH2ArCN-p) in 1,3-alternate conformation on aqueous subphase and solid substrates have been studied. Only tetra-cyanopropoxy-p-tert-butylthiacalix[4]arene 1 forms a typical monomolecular layer with perpendicular orientation of the macrocycle relative to the water-air interface that is able to immobilize cytochrome c in the entire range of the surface pressure. Obtained monolayers were transferred by Langmuir-Schaefer technique onto quartz, indium-tin oxide (ITO), and silicon. It was demonstrated that protein activity is retained after immobilization on the substrate.