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    Layer-by-Layer Assembled Multilayer Films of Methoxypoly(ethylene glycol)-block-poly( ,L-glutamic acid) and Chitosan with Reduced Cell Adhesion

    Year: 2011

    Journal: Macromolecular Bioscience, Volume 11, Issue 9, pages 1211–1217, September 09, 2011, 20110906

    Authors: Cao B. 1, Yan S. 1, Zhang K. 1, Song Z. 1, Chen X. 2, Cui L. 3

    Last authors: Lei Cui

    Organizations: 1 Department of Polymer Materials, Shanghai University, 20 Chengzhong Road, Jiading, Shanghai, China 2 Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun, China 3 Department of Plastic and Reconstructive Surgery, Shanghai 9th People's Hospital, Shanghai Jiao Tong University School of Medicine, 639 Zhizaoju Road, Shanghai 200011, China

    Country: China

    A methoxypoly(ethylene glycol)-block-poly( ,L-glutamic acid) (mPEGGA) diblock copolymer is synthesized. Using QCM measurements, it is shown that (CS/mPEGGA)n film construction takes place over two build-up stages (exponential-to-linear). UV-vis spectra reveal the regular increase of the multilayer film growth at different molecular weights of mPEGGA. Contact angle and surface morphology investigation prove that the hydrophilicity of CS/mPEGGA multilayer film-modified substrate becomes better and the surface becomes rough. Significantly reduced cell adhesion is observed on the CS/mPEGGA multilayer film coated surface.