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    Multicompartment Theranostic Nanoemulsions Stabilized by a Triphilic Semifluorinated Block Copolymer

    Year: 2017

    Journal: Mol. Pharm., Volume 14, NOV, page 3916–3926

    Authors: Barres, Alexa R.; Wimmer, Megan R.; Mecozzi, Sandro

    Organizations: National Institutes of Health [R21 EB021431]; Robert Draper Technology Innovation Fund; National Science Foundation [DGE-1256259]; Graduate School; University of Wisconsin Madison; Wisconsin Alumni Research Foundation

    Keywords: semifluorinated polymers; block copolymers; nanoemulsions; drug delivery; hydrophobic drugs; paclitaxel; F-19-MRI; theranostics

    The presence of a perfluorocarbon block in a multiblock polymer has been shown to be an additional driving force toward nanoparticle assembly. In the preparation of nanoemulsions, this perfluorocarbon block also provides enhanced particle stability. Herein, the synthesis of a new triphilic, semifluorinated copolymer, M2F8H18, is introduced. This ABC type block copolymer can be used to formulate extremely stable nanoemulsions, assembled around a lipophilic droplet, with lifetimes of one year or more. The central oil droplet can stably solubilize high concentrations of hydrophobic drugs, making this system an ideal drug delivery vehicle. The incorporation of the perfluorocarbon block modulates drug release from the lipophilic core via the surrounding fluorous shell. Fluorous imaging agents incorporated into the fluorous shell prolong drug release even further as well as provide potent F-19-MRI contrast ability. In vitro studies show that these nanoemulsions efficiently inhibit cancer cell growth, thus providing a theranostic drug delivery system.
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