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    Nanoparticle modified QCM-based sensor for lipase activity determination

    Year: 2013

    Journal: Anal. Methods, 2013,5, 3811-3815, 20131003

    Authors: Margarita Stoytcheva 1, Roumen Zlatev * 1, Zdravka Velkova 2 and Gisela Montero 1

    Last authors: Gisela Montero

    Organizations: 1 Universidad Autónoma de Baja California, Instituto de Ingeniería, Blvd. B. Juárez s/n, Mexicali, México E-mail: roumen@uabc.edu.mx; Fax: +52 686 566 4150 ; Tel: +52 686 566 4150 2 Medical University of Plovdiv, Dep. of Chemistry and Biochemistry, Blvd. V. Aprilov 15a, Plovdiv, Bulgaria

    Country: Mexico, Bulgaria

    A highly sensitive lipase activity sensor was developed and tested. It is based on the application of SiO2 nanoparticle loaded olive oil as a lipase substrate, deposited on a QCM crystal. The heavier nanoparticles’ release during the substrate enzymatic degradation causes a QCM frequency response enhancement proportional to the nanoparticle/substrate mass ratio.