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    Nanostructured electrospun nonwovens of poly(epsilon-caprolactone)/quaternized chitosan for potential biomedical applications

    Year: 2018

    Journal: Carbohydr. Polym., Volume 186, APR 15, page 110–121

    Authors: dos Santos, Danilo Martins; Leite, Ilaiali Souza; Bukzem, Andrea de Lacerda; de Oliveira Santos, Rachel Passos; Frollini, Elisabete; Inada, Natalia Mayumi; Campana-Filho, Sergio Paulo

    Organizations: Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (Brazil) [CAPES 443/2012]; Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (Brazil) [CNPq 142002/2014-3, CNPq 311250/2016-5]; Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (Brazil) [FAPESP 2010/02526-1]

    Keywords: Electrospinning; Quaternized chitosan; Biomaterial; Nonwoven; Nanofibers; Wound dressing

    Blend solutions of poly(epsilon-caprolactone) (PCL) and N-(2-hydroxy)-propyl-3-trimethylammonium chitosan chloride (QCh) were successfully electrospun. The weight ratio PCL/QCh ranged in the interval 95/5-70/30 while two QCh samples were used, namely QCh1 ((DQ) over bar = 47.3%; (DPv) over bar = 2218) and QCh2 ((DQ) over bar = 71.1%; (DPv) over bar = 1427). According to the characteristics of QCh derivative and to the QCh content on the resulting PCL/QCh nonwoven, the nanofibers displayed different average diameter (175 nm-415 nm), and the nonwovens exhibited variable porosity (57.0%-81.6%), swelling capacity (175%-425%) and water vapor transmission rate (1600 gm(-2) 24 h-2500 gm(-2) 24 h). The surface hydrophilicity of nonwovens increases with increasing QCh content, favoring fibroblast (HDFn) adhesion and spreading. Tensile tests revealed that the nonwovens present a good balance between elasticity and strength under both dry and hydrated state. Results indicate that the PCL/QCh electrospun nonwovens are new nanofibers-based biomaterials potentially useful as wound dressings.
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