Contact
    Start Publications Peptide-based coatings for flexible implantable neural ...
    ←  Publication Finder
    Attension

    Peptide-based coatings for flexible implantable neural interfaces

    Year: 2018

    Journal: Sci Rep, Volume 8, JAN 11

    Authors: Righi, Martina; Puleo, Gian Luigi; Tonazzini, Ilaria; Giudetti, Guido; Cecchini, Marco; Micera, Silvestro

    Organizations: FPT-ICT project NEBIAS [611687]; EU-FP7-M-ERA.NET; European Union FP7-NMP project MERIDIAN [280778]

    In the last decade, the use of flexible biosensors for neuroprosthetic and translational applications has widely increased. Among them, the polyimide (PO-based thin-film electrodes got a large popularity. However, the usability of these devices is still hampered by a non-optimal tissue-device interface that usually compromises the long-term quality of neural signals. Advanced strategies able to improve the surface properties of these devices have been developed in the recent past. Unfortunately, most of them are not easy to be developed and combined with micro-fabrication processes, and require long-term efforts to be testable with human subjects. Here we show the results of the design and in vitro testing of an easy-to-implement and potentially interesting coating approach for thin-film electrodes. In particular, two biocompatible coatings were obtained via covalent conjugation of a laminin-derived peptide, CAS-IKVAV-S (IKV), with polyimide sheets that we previously functionalized with vinyl- and amino- groups (Pl_v and Pl_a respectively). Both the engineered coatings (Pl_v+IKV and Pl_a+IKV) showed morphological and chemical properties able to support neuronal adhesion, neurite sprouting, and peripheral glial cell viability while reducing the fibroblasts contamination of the substrate. In particular, Pl_v+IKV showed promising results that encourage further in vivo investigation and pave the way for a new generation of peptide-coated thin-film electrodes.
    View publication