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    Preparation and characterization of brush-like PEGMA-graft-PDA coating and its application for protein separation by CE

    Year: 2014

    Journal: JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, Vol. 25, p 1306-1327, 20150722

    Authors: Chen, Lijuan; Liu, Guangming; Liu, Songtao; Bai, Longchao; Wang, Yanmei

    Organizations: Univ Sci & Technol China, Dept Polymer Sci & Engn, CAS Key Lab Soft Matter Chem, Hefei 230026, Peoples R China; Univ Sci & Technol China, Dept Chem Phys, Hefei Natl Lab Phys Sci Microscale, Hefei 230026, Peoples R China

    In this paper, a novel brush-like copolymer consisting of poly(ethylene glycol) methyl ether methacrylate and 2-aminoethyl methacrylate (AEMA) named as poly(PEGMA(300)-co-AEMA) was synthesized by atom transfer radical polymerization (ATRP), and then, poly(PEGMA(300)-co-AEMA) copolymer was immobilized onto material surfaces through polydopamine (PDA)-anchored coating. The defined copolymer structure was characterized by nuclear magnetic resonance hydrogen spectroscopy (H-1 NMR) and gel permeation chromatography (GPC). The chemical component and surface morphology of the brush-like copolymer-graft-PDA coating were studied by using X-ray photoelectron spectroscopy (XPS) and scanning electron microscope (SEM), respectively. The hydrophilicity of the brush-like copolymer-graft-PDA coating was investigated by using static water contact angle. The protein-resistant property of the brush-like copolymer-graft-PDA coating was investigated by using quartz crystal microbalance with dissipation (QCM-D), and finally the coating was applied to capillary inner surface for protein separation by capillary electrophoresis (CE).