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    Production and characterization of cellulose acetate - titanium dioxide nanotubes membrane fraxiparinized through polydopamine for clinical applications

    Year: 2018

    Journal: Carbohydr. Polym., Volume 181, FEB 1, page 215–223

    Authors: Dumitriu, Cristina; Voicu, Stefan Ioan; Muhulet, Alexandru; Nechifor, Gheorghe; Popescu, Simona; Ungureanu, Camelia; Carja, Andrea; Miculescu, Florin; Trusca, Roxana; Pirvu, Cristian

    Organizations: EU [POSCCE-A2-O2.2.1-2013-1, 638/12.03.2014, 1970, 48652]

    Keywords: Cellulose acetate membrane; Titanium dioxide nanotubes; Polydopamine; Antimicrobial activity; Hemodialysis; Fraxiparine

    The present paper introduces a study on the preparation and characterization of cellulose acetate - TiO2 nanotubes membrane. In order to be used as a hemodialysis membrane, fraxiparinized nanotubes have been incorporated into the cellulose matrix. Fraxiparine embedding was performed via strong binding ability of dopamine. Composite membrane was characterized by scanning electron microscopy, Fourier transform infrared spectroscopy, and water contact angle measurement. Electrochemical impedance spectroscopy was used to correlate the morphology of composite membrane with its electrochemical properties. Mott-Schottky test proved titanium dioxide semiconductor incorporation in composite membrane. Permeation test was made to determine pure water flux. The obtained results showed that addition of nanotubes had a positive impact on membrane permeation compared with a control polymeric membrane.
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