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    Spectral studies of Donepezil release from streched PVA polymer films

    Year: 2013

    Journal: Journal of Molecular Structure, 1044, pp 262-267, 20130926

    Authors: Cristina-Delia Nechifor, Carmen-Beatrice Zelinschi, Iuliana Stoica, Valentina Closca, Dana-Ortansa Dorohoi

    Organizations: Department of Physics, Ias i, Dimitrie Mangeron Bvd., No. 67, ‘‘Gheorghe Asachi’’ Technical University of Iasi, RO 700050, Romania, Department of Plasma Physics, Polymer Physic, Optics and Spectroscopy, Iasi, Carol I Bvd., No. 11, ‘‘AL. I. Cuza’’ University of Iasi, RO 700506, Romania, Laboratory of Physical Chemistry of Polymers, Ias i, Aleea Gr. Ghica Voda˘ 41 A, ‘‘Petru Poni’’ Institute of Macromolecular Chemistry, RO 700487, Romania

    The focus of this research is to obtain poly vinyl alcohol (PVA) polymer foils containing Donepezil in differentconcentration, in order to be used in controlled drug release as a palliative treatment of mild tomoderate Alzheimer’s disease. The influence of polymeric foil stretching degree on drug release was analyzedusing spectral measurements.Aiming to evidence the stretching degrees of PVA foils influence on drug release the membranes containing2% Donepezil were obtained and characterized. The morphology of pure PVA and polymeric filmswith Donepezil at different stretching degrees was investigated.In vitro evaluation of drug release from the polymeric foils was made for different stretching degrees.The absorbance of the solution was measured at 232 nm in each case; the amount of drug release aftereach time interval was calculated and a cumulative addition was made. The mechanism involved in drugrelease process was evaluated using Korsmeyer–Peppas empirical equation. Surface roughness and profileof drug release are affected by the stretching degree of PVA foils.The dependence of the release profile on the characteristics of polymer foils containing Donepezil andthe manner in which the stretching degree of the PVA with Donepezil films modify the kinetics of drugrelease were emphasized in this study.