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    Swelling of Poly(DL-lactide) and Polylactide-co-glycolide in Humid Environments

    Year: 2001

    Journal: Macromolecules 2001, 34, 8752-8760, 20100827

    Authors: Sharp J. S., Forrest J. A., Jones R. A. L.

    Last authors: R. A. L. Jones

    Organizations: Department of Physics and Astronomy, University of Sheffield, Hounsfield Rd., Sheffield, England S3 7RH, and Department of Physics, University of Waterloo, Waterloo, Ontario, Canada N2L 3G1

    Country: Canada

    The water uptake of poly(DL-lactide) (PLA) and its copolymer with glycolic acid (PLGA 50:50) has been studied using a quartz crystal microbalance (QCM). The polymers were swollen in humid atmospheres at 20 °C in order to probe both the kinetics of adsorption and the equilibrium amount of water taken up at low concentrations. The relative humidity of the air was controlled using saturated
    salt solutions. By equating the chemical potentials of the water vapor and the polymer/water mixture at equilibrium, it was possible to extract the Flory-Huggins interaction parameter ø from a simple binary mixing theory. Studies were also performed on the formulations of these materials with a model polypeptide active ingredient. The kinetics of swelling were described using a model based on the Thomas-Windle model of penetrant diffusion in glassy polymers.