Start Publications Synthesis of Single-Chain Sugar Arrays†
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Synthesis of Single-Chain Sugar Arrays†

Year: 2013

Journal: Angewandte Chemie Volume 125, Issue 8, pages 2391–2395, February 18, 2013, 20130630

Authors: Nathalie Baradel 1, Dr. Sébastien Fort 2, Dr. Sami Halila 2, Dr. Nezha Badi 1, Dr. Jean-François Lutz 1

Last authors: Dr. Jean-François Lutz

Organizations: 1
Precision Macromolecular Chemistry, Institut Charles Sadron, UPR22-CNRS, 23 rue du Loess, BP84047, 67034 Strasbourg Cedex 2 (France) 2
Oligosaccharides Chemistry and Biotechnology, Centre de Recherches sur les Macromolécules Végétales (CERMAV-CNRS), BP 53, 38041 Grenoble Cedex 9 (France) Email: Dr. Jean-François Lutz (jflutz@unistra.fr) *Precision Macromolecular Chemistry, Institut Charles Sadron, UPR22-CNRS, 23 rue du Loess, BP84047, 67034 Strasbourg Cedex 2 (France)

Country: France

Polymers that toe the line: Well-defined linear polystyrene chains containing precisely positioned hexose moieties (mannose, galactose, and N-acetylglucosamine) were synthesized by a sequence-controlled polymerization approach followed by a series of site-selective modification steps. Such multifunctional single-chain hexose arrays associate specifically with complementary lectins (see picture).