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    tert-Butylthiacalix[4]arene monolayers as a biomimetic model for the oxidation of antioxidants with cytochrome с

    Year: 2011

    Journal: Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 9, pp. 1915–1921, September, 2011., 20121205

    Authors: N. B. Mel'nikova, E. N. Kochetkov, S. E. Solon'eva, E. V. Popova, I. S. Anipin, A. E. Bol'shakova, O. E. Zhil'tsova, A. I. Konovalov

    Organizations: Nizhny Novgorod State Medical Academy, 10/1 pl. Minina, 603600 Nizhny Novgorod, Russian Federation.

    The possibility of designing a model of sensor to antioxidants based on thiacalix[4]arene monolayers with immobilized cytochrome c was shown. The molecular surface area S 0 of thiacalix[4]arene in the monolayers and the surface pressure coefficient −dπ/dS (elasticity) reflect changes in the redox state of cytochrome c in the presence of dihydroquercetin and ascorbic acid in the aqueous subphase. The absorption spectra in the visible and UV ranges of solutions of the subphase and transferred thiacalix[4]arene monolayers with immobilized cytochrome c confirm the oxidation of the antioxidants to quinones and formation of the reduced form of cytochrome c.