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    A bioprosthetic heart valve material prepared by copolymerization of 2-Amino-4-pentanoic acid modified pericardium and N, N-Dimethylacrylamide

    Year: 2022

    Journal: Compos. Pt. B-Eng., Volume 243, AUG 15

    Authors: Ding, Kailei; Zheng, Cheng; Huang, Xueyu; Yang, Li; Lei, Yang; Wang, Yunbing

    Organizations: CAMS Innovation Fund for Medical Sciences [2021-I2M-5-013]; National Natural Science Foundation of China [32071357]; Chengdu Major Science and Technology Innovation Programs [2019-YF08-00235-GX]; Sichuan Science and Technology Program [2021YFH0011]; National Key Research and Development Programs, China [2020YFC1107802]; 111 Project of Introducing Talents of Discipline to Universities, China [B16033]

    Keywords: Co-crosslinking; Bioprosthetic heart valve; poly(N; N-dimethylacrylamide); Structural stability; Hemocompatibility; Anti-Calcification

    Bioprosthetic heart valve thrombosis (BHVT) is no longer considered a rare clinical entity in recent years and could cause valve motion abnormalities, which requires reoperation. Currently reported modifications of bio-prosthetic heart valves (BHVs) mainly focused on improving the anti-calcification property. However, it was hard to improve their anti-thrombogenicity and crosslinking efficiency at the same time. Here we reported a method that combines improved hemocompatibility, crosslinking efficiency, cytocompatibility, and anti-calcification property for BHVs. Porcine pericardia (PPs) and 2-amino-4-pentanoic acid (APA) were first co-crosslinked with glutaraldehyde to introduce allyl moieties to the PPs, then poly(N, N-dimethylacrylamide) (PDMAA) was covalently immobilized on PPs through radical polymerization. In vitro and in vivo studies demonstrated that the structural stability of PDMAA modified PPs was much superior than that of traditional glutaraldehyde cross -linked PPs (GA). The PDMAA modified PPs exhibited enhanced antithrombogenic performance with a 75% decrease of platelet adhesion compared with GA. Moreover, the calcium content accumulated on the modified PPs after 90-day rat subcutaneous implantation decreased 93.5% compared with that on GA. The PDMAA modified PPs may alleviate BHVT and calcification, offering a potential option for BHVs fabrication in the future.
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