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    A cell retrievable strategy for harvesting extracellular matrix as active biointerface

    Year: 2022

    Journal: J. Mater. Sci. Technol., Volume 130, DEC 10, page 44–52

    Authors: Dong, Xiangyu; Zhang, Shuxiang; Xu, Yi; Chen, Longquan; Wei, Qiang; Zhao, Changsheng

    Organizations: National Natural Science Foundation of China [51973129, 320 0 0951]; Sichuan Science and Technology Program [2020YFH0034]

    Keywords: Extracellular matrix; Regenerative medicine; Biocoatings; Cell sheets; Differentiation

    Extracellular matrix (ECM) provides a variety of physical and chemical cues for cells. Here, a very simple and smart method is developed to glue living cells away for harvesting their ECMs. The obtained ECM coatings show less cell fragment residues comparing with those obtained by the traditional cell lysis. The glued cell sheets can even be re-cultured and reused after transferring to new environment. This moderate way well maintains the activity of the ECM proteins, which can promote cell adhesion and growth. Strikingly, the ECM coatings acquired from different functional cells can guide stem cell differentiation, which is attributed to the natural physical and biochemical cues on ECM coatings. Consequently, this method provides a substantial progress for preparing natural ECM coatings and shows promising potential in regenerative medicine and other related fields of biomedical engineering. ?? 2022 Published by Elsevier Ltd on behalf of The editorial office of Journal of Materials Science & Technology.
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