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    A hydrophobic antifouling surface coating on bioprosthetic heart valves for enhanced antithrombogenicity

    Year: 2022

    Journal: J. Biomed. Mater. Res. Part B, Volume 110, MAY, page 1082–1092

    Authors: Li, Meiling; Zheng, Cheng; Zhang, Shumang; Wu, Binggang; Ding, Kailei; Huang, Xueyu; Lei, Yang; Wang, Yunbing

    Organizations: Applied Basic Research of Science and Technology Projects of Sichuan Province [2018JY0538]; National Natural Science Foundation of China [31700833, 32071357]

    Keywords: antifouling; fluoride; hydrophobic; pericardium

    Thrombosis is an important factor that causes the failure of artificial biological valves in addition to calcification and immune rejection. A hydrophobic antifouling surface can improve blood compatibility by reducing the absorption of protein. In this study, porcine pericardium was cross-linked with glycidyl methacrylate, and carbon-carbon double bonds were introduced. Then, fluoride monomer was added so that the pericardial surface would become hydrophobic and antifouling. Fluoride modification changed the hydrophilicity of the pericardium surface, and the surface water contact angle increased from 84 degrees to 143 degrees. Compared with unmodified pericardium, the adsorption of bovine serum albumin and fibrinogen decreased by 93.1% and 85%, respectively, and the anti-thrombogenicity was greatly enhanced.
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