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    A novel phenolic compounds delivery system: Oral films with extract from camu-camu industrial residue

    Year: 2022

    Journal: J. Appl. Polym. Sci., Volume 139, MAY 10

    Authors: Monaco Lourenco, Carla Alves; Garcia, Vitor Augusto; Borges, Josiane Goncalves; Pedroso Yoshida, Cristiana Maria; Vanin, Fernanda Maria; de Carvalho, Rosemary Aparecida

    Organizations: Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior; National Council for Scientific and Technological Development; Sao Paulo Research Foundation

    Keywords: Myrciaria dubia; total phenolic compounds; carboxymethylcellulose; hydroxypropylmethylcellulose; starch

    Oral films perform promising alternatives to traditional oral delivery systems to carry and deliver bioactive compounds directly into the oral cavity. The objective of this work was to produce and evaluate oral films based on carboxymethylcellulose (CMC), hydroxypropyl methylcellulose (HPMC) and pregelatinized starch incorporated with ethanolic extract from camu-camu industrial residue (EECCIR). Although all films can be ingested without causing irritation to the oral mucosa, due to near-neutral surface pH, the starch-based oral films with and without the addition of EECCIR showed reduced tensile strength (5.48 +/- 0.97 MPa) indicating inferior mechanical properties to films based on CMC and HPMC. The CMC films, in addition to shorter disintegration time (50 +/- 5 s), showed faster release, about 70% of phenolic compounds in 10 min and 100% in 30 min. As for the release profile, the application of the Korsmeyer and Peppas and Peppas and Sahlin models allowed to better understand the mechanisms involved in the release of phenolic compounds. Although all three oral film formulations can be used as carriers of active compounds from the ethanolic extract of the camu-camu residue, the oral films based on CMC incorporated with EECCIR showed greater potential.
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