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    A Supported Lipid Bilayer-Based Lab-on-a-Chip Biosensor for the Rapid Electrical Screening of Coronavirus Drugs

    Journal: ACS Sens.

    Authors: Zhou, Feng; Pan, Wenwei; Chang, Ye; Su, Xueyou; Duan, Xuexin; Xue, Qiannan

    Organizations: National Key R&D Program of China [2021YFC3002202]; 111 Project [B07014]; Scienti fi c Research Transformation Foundation of Wenzhou Safety (Emergency) Institute of Tianjin University

    Keywords: lipid bilayers; lab-on-a-chip; drugs screening; coronavirus drugs; extended gate-type FET

    With the rapid spread and multigeneration variation of coronavirus, rapid drug development has become imperative. A major obstacle to addressing this issue is adequately constructing the cell membrane at the molecular level, which enables in vitro observation of the cell response to virus and drug molecules quantitatively, shortening the drug experiment cycle. Herein, we propose a rapid and label-free supported lipid bilayer-based lab-on-a-chip biosensor for the screening of effective inhibition drugs. An extended gate electrode was prepared and functionalized by an angiotensin-converting enzyme II (ACE2) receptor-incorporated supported lipid bilayer (SLB). Such an integrated system can convert the interactions of targets and membrane receptors into real-time charge signals. The platform can simulate the cell membrane microenvironment in vitro and accurately capture the interaction signal between the target and the cell membrane with minimized interference, thus observing the drug action pathway quantitatively and realizing drug screening effectively. Due to these label-free, low-cost, convenient, and integrated advantages, it is a suitable candidate method for the rapid drug screening for the early treatment and prevention of worldwide spread of coronavirus.
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