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    Antibacterial and Remineralizing Fillers in Experimental Orthodontic Adhesives

    Year: 2019

    Journal: Materials, Volume 12, FEB 2

    Authors: Ferreira, Carolina Jung; Branco Leitune, Vicente Castelo; Balbinot, Gabriela de Souza; Degrazia, Felipe Weidenbach; Arakelyan, Marianna; Sauro, Salvatore; Collares, Fabricio Mezzomo

    Organizations: Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior-Brasil (CAPES) [001]

    Keywords: adhesive; orthodontic; mineral deposition; anti-bacterial agents; quaternary ammonium compounds; boron nitride

    Orthodontic adhesives with antimicrobial and remineralizing properties may be an alternative to control white spot lesions around brackets. The aim of this study is to develop an experimental orthodontic adhesive containing boron nitride nanotubes (BNNT) and alkyl trimethyl ammonium bromide (ATAB). Methacrylate (BisGMA and TEGDMA) monomers were used to formulate the adhesives. Four experimental groups were produced with the addition of 0.1 wt.% BNNT (G(BNNT)); 0.1 wt.% ATAB (G(ATAB)); and 0.2 wt.% BNNT with ATAB (G(BNNT/ATAB)); in the control group, no fillers were added (G(Ctrl)). The degree of conversion, cytotoxicity, softening in solvent, contact angle and free surface energy, antibacterial activity, shear bond strength, and mineral deposition were evaluated. Adhesives achieved degree of conversion higher than 50% and cell viability higher than 90%. G(BNNT) and G(ATAB) adhesives exhibited reduced softening in solvent. Mean free surface energy was decreased in the G(BNNT) adhesive. Significant reduction in bacterial growth was observed in the G(BNNT/ATAB). No statistical difference was found for shear bond strength. Mineral deposition was found in G(BNNT), G(ATAB), and G(BNNT/ATAB) groups after 14 and 28 days. The addition of 0.2% BNNT/ATAB to an experimental orthodontic adhesive inhibited bacterial growth and induced mineral deposition without affecting the properties of the material.
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