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    Antibacterial, chemical and physical properties of sealants with polyhexamethylene guanidine hydrochloride

    Year: 2019

    Journal: Braz. Oral Res., Volume 33

    Authors: Garcia, Isadora Martini; Rodrigues, Stefani Becker; Branco Leitune, Vicente Castelo; Collares, Fabricio Mezzomo

    Organizations: Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior - Brasil (CAPES)Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) [001]

    Keywords: Pit and Fissure Sealants; Methacrylates; Polymerization; Anti-Bacterial Agents

    The aim of this study was to evaluate the influence of polyhexamethylene guanidine hydrochloride (PHMGH) in the physicochemical properties and antibacterial activity of an experimental resin sealant. An experimental resin sealant was formulated with 60 wt.% of bisphenol A glycol dimethacrylate and 40 wt.% of triethylene glycol dimethacrylate with a photoinitiator/co-initiator system. PHMGH was added at 0.5 (G(0.5%)), 1 (G(1%)), and 2 (G(2%)) wt.% and one group remained without PHMGH, used as control (G(CTRL)). The resin sealants were analyzed for degree of conversion (DC), Knoop hardness (KHN), and softening in solvent (Delta KHN), ultimate tensile strength (UTS), contact angle (theta) with water or a-bromonaphthalene, surface free energy (SFE), and antibacterial activity against Streptococcus mutans for biofilm formation and planktonic bacteria. There was no significant difference for DC (p > 0.05). The initial Knoop hardness ranged from 17.30 (+/- 0.50) to 19.50 (+/- 0.45), with lower value for G(CTRL) (p < 0.05). All groups presented lower KHN after immersion in solvent (p < 0.05). The Delta KHN ranged from 47.22 (+/- 4.30) t o 5 7.22 (+/- 5.42)%, without significant difference (p > 0.05). The UTS ranged from 54.72 (+/- 11.05) M Pa t o 6 0.46 (+/- 6.50) MPa, with lower value for G(2%) (p < 0.05). PHMGH groups presented no significant difference compared to G(CTRL) in. (p > 0.05). G(2%) showed no difference in SFE compared to G(CTRL) (p > 0.05). The groups with PHMGH presented antibacterial activity against biofilm and planktonic bacteria, with higher antibacterial activity for higher PHMGH incorporation (p < 0.05). PHMGH provided antibacterial activity for all resin sealant groups and the addition up to 1 wt.% showed reliable physico-chemical properties, maintaining the caries-protective effect of the resin sealant over time.
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