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    Antibacterial properties of sophorolipid-modified gold surfaces against Gram positive and Gram negative pathogens

    Year: 2017

    Journal: Colloid Surf. B-Biointerfaces, Volume 157, SEP 1, page 325–334

    Authors: Valotteau, Claire; Banat, Ibrahim M.; Mitchell, Christopher A.; Lydon, Helen; Marchant, Roger; Babonneau, Florence; Pradier, Claire-Marie; Baccile, Niki; Humblot, Vincent

    Keywords: Sophorolipid; Self-assembled monolayers; Antibacterial surface; Membrane-damaging activity

    Sophorolipids are bioderived glycolipids displaying interesting antimicrobial properties. We show that they can be used to develop biocidal monolayers against Listeria ivanovii, a Gram-positive bacterium. The present work points out the dependence between the surface density and the antibacterial activity of grafted sophorolipids. It also emphasizes the broad spectrum of activity of these coatings, demonstrating their potential against both Gram-positive strains (Enteroccocus faecalis, Staphylococcus epidermidis, Streptococcus pyogenes) and Gram-negative strains (Escherichia coli, Pseudomonas aeruginosa and Salmonella typhymurium). After exposure to sophorolipids grafted onto gold, all these bacterial strains show a significant reduction in viability resulting from membrane damage as evidenced by fluorescent labelling and SEM-FEG analysis. (C) 2017 Elsevier B.V. All rights reserved.
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