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    Antimicrobial graphene-based coatings for biomedical implant applications

    Year: 2023

    Journal: Carbon Trends, Volume 12, 2023-09-01, page 100282

    Authors: Romo-Rico, Jesus; Bright, Richard; Krishna, Smriti Murali; Vasilev, Krasimir; Golledge, Jonathan; Jacob, Mohan V.

    Keywords: Graphene; Coatings; Antimicrobial; Biocompatible; Implant

    Implant-associated infections (IAI) cause significant health issues and healthcare costs. In this research, we deposited graphene (Gr) on a medical-grade cobalt-chromium (CoCr) alloy surface by radiofrequency plasma-enhanced chemical vapor deposition (RF-PECVD) using Origanum vulgare as a precursor material. The deposition of Gr on the CoCr was confirmed using Raman spectroscopy and X-Ray photoelectron spectroscopy (XPS) and scanning electron microscopy (SEM). The biocompatibility and antibacterial properties of CoCr-Gr were investigated. CoCr-Gr was biocompatible and promoted cell adhesion and spreading of RAW 267.4 macrophage cells. CoCr-Gr were antibacterial against Staphylococcus aureus and Pseudomonas aeruginosa and inhibited P. aeruginosa attachment. The results indicate that CoCr-Gr could be used as a potential antibacterial coating material for implantable devices.
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