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    Antimicrobial PHAs coatings for solid and porous tantalum implants

    Year: 2019

    Journal: Colloid Surf. B-Biointerfaces, Volume 182, 1-Oct

    Authors: Rodriguez-Contreras, Alejandra; Guillem-Marti, Jordi; Lopez, Oscar; Manero, Jose Maria; Ruperez, Elisa

    Organizations: Spanish Government (MINECO/FEDER) [MAT2015-67103-C4-3-R]; Agency for Administration of University and Research Grants of the Government of Catalonia [2014 SGR 1333]

    Keywords: Porous tantalum; Biodegradable biopolymers; Gentamicin; Dip-coating technique; Polyhydroxyalkanoates; Trabecular metal

    Biomaterial-associated infections (BAI) are the major cause of failure of indwelling medical devices. The risk of BAI can end dramatically in the surgical removal of the affected device. Therefore, a major effort must be undertaken to guarantee the permanence of the implant. In this regard, we have developed antimicrobial coatings for tantalum (Ta) implants, using polyhydroxyalkanoates (PHAs) as matrices for carrying an active principle. The dip-coating technique was successfully used for covering solid Ta discs. An original PHA emulsion flow process was developed for the coating of porous Ta structures, specially for the inner surfaces. The complete characterization of the biopolymer coatings, their antibacterial properties, toxicity and biointegration were analyzed. Thus, non-toxic, well-biointegrated homogeneous biopolymer coatings were attained, which showed antibacterial properties. By using biodegradable PHAs, the resulting drug delivery system assured the protection of Ta against bacterial infections for a period of time.
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