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    Antimicrobial Porous Surfaces Prepared by Breath Figures Approach

    Year: 2018

    Journal: Materials, Volume 11, AUG

    Authors: Munoz-Bonilla, Alexandra; Cuervo-Rodriguez, Rocio; Lopez-Fabal, Fatima; Gomez-Garces, Jose L.; Fernandez-Garcia, Marta

    Organizations: MINECO [MAT2016-78437-R]; Agencia Estatal de Investigacion (AEI, Spain); Fondo Europeo de Desarrollo Regional (FEDER, EU)

    Keywords: antimicrobial coatings; porous surfaces; breath figures

    Herein, efficient antimicrobial porous surfaces were prepared by breath figures approach from polymer solutions containing low content of block copolymers with high positive charge density. In brief, those block copolymers, which were used as additives, are composed of a polystyrene segment and a large antimicrobial block bearing flexible side chain with 1,3-thiazolium and 1,2,3-triazolium groups, PS54-b-PTTBM-M-44, PS54-b-PTTBM-B-44, having different alkyl groups, methyl or butyl, respectively. The antimicrobial block copolymers were blended with commercial polystyrene in very low proportions, from 3 to 9 wt %, and solubilized in THF. From these solutions, ordered porous films functionalized with antimicrobial cationic copolymers were fabricated, and the influence of alkylating agent and the amount of copolymer in the blend was investigated. Narrow pore size distribution was obtained for all the samples with pore diameters between 5 and 11 mu m. The size of the pore decreased as the hydrophilicity of the system increased; thus, either as the content of copolymer was augmented in the blend or as the copolymers were quaternized with methyl iodide. The resulting porous polystyrene surfaces functionalized with low content of antimicrobial copolymers exhibited remarkable antibacterial efficiencies against Gram positive bacteria Staphylococcus aureus, and Candida parapsilosis fungi as microbial models.
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