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    Application of scanning electrochemical microscopy for topography imaging of supported lipid bilayers

    Year: 2022

    Journal: Anal. Methods, Volume 14, MAR 10, page 1077–1082

    Authors: Nasri, Zahra; Memari, Seyedali; Striesow, Johanna; Weltmann, Klaus-Dieter; von Woedtke, Thomas; Wende, Kristian

    Organizations: German Federal Ministry of Education and Research (BMBF) [03Z22DN12]

    Oxidative stress in cellular environments may cause lipid oxidation and membrane degradation. Therefore, studying the degree of lipid membrane morphological changes by reactive oxygen and nitrogen species will be informative in oxidative stress-based therapies. This study introduces the possibility of using scanning electrochemical microscopy as a powerful imaging technique to follow the topographical changes of a solid-supported lipid bilayer model induced by reactive species produced from gas plasma. The introduced strategy is not limited to investigating the effect of reactive species on the lipid bilayer but could be extended to understand the morphological changes of the lipid bilayer due to the action of membrane proteins or antimicrobial peptides.
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