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    Bactericidal surfaces prepared by femtosecond laser patterning and layer-by-layer polyelectrolyte coating

    Year: 2020

    Journal: J. Colloid Interface Sci., Volume 575, SEP 1, page 286–297

    Authors: Chen, Chao; Enrico, Alessandro; Pettersson, Torbjorn; Ek, Monica; Herland, Anna; Niklaus, Frank; Stemme, Goran; Wagberg, Lars

    Organizations: Chinese Scholarship CouncilChina Scholarship Council [201407930001]; Swedish Foundation for Strategic Research (SSF)Swedish Foundation for Strategic Research [GMT14-0071]; Wallenberg Wood Science Centre

    Keywords: Antimicrobial; Cationic polyelectrolytes; Ultrashort pulse laser; Escherichia coli; Staphylococcus aureus

    Antimicrobial surfaces are important in medical, clinical, and industrial applications, where bacterial infection and biofouling may constitute a serious threat to human health. Conventional approaches against bacteria involve coating the surface with antibiotics, cytotoxic polymers, or metal particles. However, these types of functionalization have a limited lifetime and pose concerns in terms of leaching and degradation of the coating. Thus, there is a great interest in developing long-lasting and non-leaching bactericidal surfaces. To obtain a bactericidal surface, we combine micro and nanoscale patterning of borosilicate glass surfaces by ultrashort pulsed laser irradiation and a non-leaching layer-by-layer polyelectrolyte modification of the surface. The combination of surface structure and surface charge results in an enhanced bactericidal effect against both Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli bacteria. The laser patterning and the layer-by-layer modification are environmentally friendly processes that are applicable to a wide variety of materials, which makes this method uniquely suited for fundamental studies of bacteria-surface interactions and paves the way for its applications in a variety of fields, such as in hygiene products and medical devices. (C) 2020 The Authors. Published by Elsevier Inc.
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