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    Bi-Layered Polymer Carriers with Surface Modification by Electrospinning for Potential Wound Care Applications

    Year: 2019

    Journal: Pharmaceutics, Volume 11, DEC

    Authors: Palo, Mirja; Ronkonharju, Sophie; Tiirik, Kairi; Viidik, Laura; Sandler, Niklas; Kogermann, Karin

    Organizations: Estonian Research CouncilEstonian Research Council; Estonian Ministry of Education and ResearchMinistry of Education and Research, Estonia [PUT1088]; Erasmus Scholarships

    Keywords: electrospinning; wound dressings; solvent casting; 3D printing; polymeric carrier

    Polymeric wound dressings with advanced properties are highly preferred formulations to promote the tissue healing process in wound care. In this study, a combinational technique was investigated for the fabrication of bi-layered carriers from a blend of polyvinyl alcohol (PVA) and sodium alginate (SA). The bi-layered carriers were prepared by solvent casting in combination with two surface modification approaches: electrospinning or three-dimensional (3D) printing. The bi-layered carriers were characterized and evaluated in terms of physical, physicochemical, adhesive properties and for the safety and biological cell behavior. In addition, an initial inkjet printing trial for the incorporation of bioactive substances for drug delivery purposes was performed. The solvent cast (SC) film served as a robust base layer. The bi-layered carriers with electrospun nanofibers (NFs) as the surface layer showed improved physical durability and decreased adhesiveness compared to the SC film and bi-layered carriers with patterned 3D printed layer. Thus, these bi-layered carriers presented favorable properties for dermal use with minimal tissue damage. In addition, electrospun NFs on SC films (bi-layered SC/NF carrier) provided the best physical structure for the cell adhesion and proliferation as the highest cell viability was measured compared to the SC film and the carrier with patterned 3D printed layer (bi-layered SC/3D carrier). The surface properties of the bi-layered carriers with electrospun NFs showed great potential to be utilized in advanced technical approach with inkjet printing for the fabrication of bioactive wound dressings.
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