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    Binder jetting 3D printing of challenging medicines: From low dose tablets to hydrophobic molecules

    Year: 2022

    Journal: Eur. J. Pharm. Biopharm., Volume 170, JAN, page 144–159

    Authors: Kozakiewicz-Latala, Marta; Nartowski, Karol P.; Dominik, Aleksandra; Malec, Katarzyna; Golkowska, Anna M.; Zlocinska, Adrianna; Rusinska, Malgorzata; Szymczyk-Ziolkowska, Patrycja; Ziolkowski, Grzegorz; Gorniak, Agata; Karolewicz, Bozena

    Organizations: Ministry of Science and Higher Education [SUB.D190.20.004]

    Keywords: Inkjet printing; 3DP; Additive manufacturing; Fast dissolving tablets; Wettability; Clotrimazole; Quinapril; Spray drying

    Increasing access to additive manufacturing technologies utilising easily available desktop devices opened novel ways for formulation of personalized medicines. It is, however, challenging to propose a flexible and robust formulation platform which can be used for fabrication of tailored solid dosage forms composed of APIs with different properties (e.g., hydrophobicity) without extensive optimization. This manuscript presents a strategy for formulation of fast dissolving tablets using binder jetting (BJ) technology. The approach is demonstrated using two model APIs: hydrophilic quinapril hydrochloride (QHCl, logP = 1.4) and hydrophobic clotrimazole (CLO, logP = 5.4). The proposed printing method uses inexpensive, well known, and easily available FDA approved pharmaceutical excipients. The obtained model tablets had uniform content of the drug, excellent mechanical properties, and highly porous structure resulting in short disintegration time and fast dissolution rate. The tablets could be scaled and obtained in predesigned shapes and sizes. The proposed method may find its application in the early stages of drug development where high flexibility of the formulation is required and the amount of available API is limited.
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