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    Biodegradable anastomotic tube prepared from diblock copolymers of mPEG-b-PLA and mPEG-b-PLGA

    Year: 2019

    Journal: J. Macromol. Sci. Part A-Pure Appl. Chem., Volume 56, JUL 3, page 667–675

    Authors: Zhang, Xiaodong; Yu, Zuoqian; Jiang, Feizhao; Ye, Lechi; Li, Jinlei; Ye, Xingzhao; Xing, Chungen

    Organizations: Zhejiang Provincial Natural Science Foundation of ChinaNatural Science Foundation of Zhejiang Province [LY15H160058]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81572291]; Zhejiang Provincial Medical technology science project - Suzhou Key Medical Center [2015KYB245, LCZX201505]; Chinese Natural Science FoundationNational Natural Science Foundation of China (NSFC) [81672970]; Second Affiliated Hospital of Soochow University Preponderant Clinic Discipline Group Project Funding [2015.07]

    Keywords: Anastomotic tube; biodegradable; diblock copolymer; nanofibrous film

    During the healing and reconstruction process of digestive tract, biodegradable anastomat plays an important role. Various of materials have been explored to prepare suitable anastomat. However, the biodegradable ratio or biocompatibility could not meet the requirement of wound healing in clinical application. To overcome these obstacles, we synthetized methoxy-poly(ethylene glycol)-block-polylactide (mPEG-b-PLA) and methoxy-poly(ethylene glycol)-block-poly(lactide-co-glycolide) (mPEG-b-PLGA) with different molecular weight. Biodegradable anastomotic tubes were prepared from these diblock copolymers using electrospinning technique. The thickness of anastomotic tube could be regulated by spinning conditions. Anastomotic tubes had exhibited excellent hemocompatibility (hemolysis ratios were ranged from 0.5% to 1.5%) and cytocompatibility. After 3days, epithelial cells were adhered closely and covered fully on the surface of nanofibrous tubes. Moreover, mPEG-b-PLGA(3) based anastomotic tube had play an important role to improve the healing and reconstruction process of cecal incision. The biodegradable anastomotic tubes from diblock copolymers of mPEG-b-PLA and mPEG-b-PLGA could promote healing and reconstruction of digestive tract and might play an important role after operation.
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