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    Bioinspired Polymeric Coating with Self-Adhesion, Lubrication, and Drug Release for Synergistic Bacteriostatic and Bactericidal Performance

    Year: 2022

    Journal: Adv. Mater. Interfaces, Volume 9, SEP

    Authors: Wang, Haimang; Yang, Yuhe; Zhao, Weiwei; Han, Ying; Luo, Jing; Zhao, Xin; Zhang, Hongyu

    Organizations: National Natural Science Foundation of China [52022043, 82122002]; Tsinghua University-Peking Union Medical College Hospital Initiative Scientific Research Program [20191080593]; Precision Medicine Foundation, Tsinghua University, China [10001020120]; Capital's Funds for Health Improvement and Research [2020-2Z-40810]; Research Fund of State Key Laboratory of Tribology, Tsinghua University, China [SKLT2022C18]; Shenzhen Basic Research Project, Shenzhen Science and Technology Innovation Committee [2021Szvup141]

    Keywords: dopamine; hydration lubrication; phosphorylcholine coating; self-assembly; surface functionalization

    A combination of surface lubrication and antibacterial performance is highly imperative for biomedical implants in clinic. In this study, motivated by mussel-inspired adhesion, articular cartilage superlubrication, and drug-loading capacity of cyclodextrins, a new copolymer of p(DMA-MPC-CD) (namely PDMC) with self-adhesion, lubrication, and drug loading & release properties is developed for fabricating a versatile platform to construct a synergistic bacteriostatic/bactericidal surface. Specifically, the biomimetic coating is prepared via polydopamine mediated layer-by-layer (LBL) self-assembly method on the surface of titanium alloy (Ti6Al4V), and characterized by quartz crystal microbalance, X-ray photoelectron spectroscopy, and surface wettability to confirm the modification process. The biocompatibility evaluation using L929 cells shows that the coating, even with pre-loaded bactericide, presents satisfied biocompatibility in vitro. Additionally, the enhanced lubrication and bacterial resistance properties of copolymer-coated Ti6Al4V (Ti6Al4V@PDMC) are attributed to the tenacious hydration shell that is formed surrounding the zwitterionic phosphorylcholine charges. Furthermore, the bactericidal function of the biomimetic coating is successfully achieved by releasing the pre-loaded bactericide in a sustained manner, which effectively kills the adhered bacteria on the surface. In summary, the bioinspired surface functionalization strategy developed here may act as a universal and promising method for achieving enhanced lubrication and synergistic bacteriostatic/bactericidal properties in biomedical implants.
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