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    Bioinspired Polysaccharide Derivative with Efficient and Stable Lubrication for Silicon-Based Devices

    Journal: Biomacromolecules

    Authors: Gao, Luyao; Zhao, Xiaoduo; Zhang, Yunlei; Yang, Lumin; Wang, Rui; Ma, Zhengfeng; Liang, Yong-min; Ma, Shuanhong; Zhou, Feng

    Organizations: National Natural Science Foundation of China [22032006, 52075522]; Outstanding Youth Fund of Gansu Province [21JR7RA095]; Key Research Project of Shandong Provincial Natural Science Foundation [ZR2021ZD27]; Major Program of the Lanzhou Institute of Chemical Physics, CAS [ZYFZFX-2, ZYFZFX-4]; Youth Innovation Promotion Association [2019411]; LICP Cooperation Foundation for Young Scholars [HZJJ21-04]

    It is becoming increasingly important to synthesize efficient biomacromolecule lubricants suitable for medical devices. Even though the development of biomimetic lubricants has made great progress, the current system suitable for hydrophobic silicone-based medical devices is highly limited. In this work, we synthesize one kind of novel polysaccharide-derived macromolecule lubricant of chitosan (CS) grafted polyethylene glycol (PEG) chains and catechol groups (CT) (CS-g-PEG-g-CT). CS-g-PEG-g-CT shows good adsorption ability by applying quantitative analysis of quartz crystal microbalance (QCM), attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR), and confocal fluorescence imaging technique, as well as the typical shear thinning feature. CS-g-PEG-g-CT exhibits low and stable coefficients of friction (COFs) (0.01-0.02) on polydimethylsiloxane (PDMS) surfaces at a wide range of mass concentrations in diverse media including pure water, physiological saline, and PBS buffer solution and is even tolerant to various normal loads and sliding frequencies for complex pressurizing or shearing environments. Subsequently, systematic surface characterizations are used to verify the dynamic attachment ability of the CS-g-PEG-g-CT lubricant on the loading/shearing process. The lubrication mechanism of CS-g-PEG-g-CT can be attributed to the synergy of strong adsorption from catechol groups to form a uniform assembly layer, excellent hydration effect from PEG chains, and typical shear thinning feature to dissipate viscous resistance. Surprisingly, CS-g-PEG-g-CT exhibits efficient lubricity on silicone-based commercial contact lenses and catheters. The current macromolecule lubricant demonstrates great real application potential in the fields of medical devices and disease treatments.
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