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    Bis(nitroxide) methanofullerene as SOD-mimetic in reactions with catecholamines

    Year: 2019

    Journal: Russ. Chem. Bull., Volume 68, JAN, page 149–157

    Authors: Melnikova, N. B.; Solovyeva, O. N.; Muzykina, V. M.; Gubskaya, V. P.; Fazleeva, G. M.; Poddelsky, A., I

    Keywords: dopamine; nitroxides; fullerenes; SOD-mimetics; phytic acid

    The reactions of a SOD-mimetic, bis(nitroxide) methanofullerene, with dopamine and 6-hydroxydopamine and the properties of its adsorption and Langmuir mono- and transferred layers were studied by methods of UV spectroscopy and EPR. The used fullerene derivative oxidizes catecholamines to cyclic and noncyclic quinones, whereas in a medium of phytic acid their oxidation products can be reduced. The inhibition effect of nitroxide fullerene in a phytic acid medium on the autocatalytic process of dopamine oxidation to its neurotoxic metabolite can be used for both the biomimetic prediction of stability of catecholamines and therapy of neurodegenerative diseases.
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