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    Boron nitride decorated poly(vinyl alcohol)/poly(acrylic acid) composite nanofibers: A promising material for biomedical applications

    Year: 2023

    Journal: Journal of the Mechanical Behavior of Biomedical Materials, Volume 141, 2023-05-01, page 105773

    Authors: Doğan, Deniz; Karaduman, F. Rabia; Horzum, Nesrin; Metin, Ayşegül Ülkü

    Keywords: Boron nitride; Electrospun fiber; Mechanical; Thermal and biological properties

    In this study, polyvinyl alcohol (PVA) and polyacrylic acid (PAA) nanofibers loaded with boron nitride nanoparticles (mBN) were fabricated by using electrospinning and crosslinked by heat treatment. The physical, chemical, and mechanical properties, hydrophilic behavior, and degradability of composite nanofibers were evaluated. The mechanical properties such as elastic modulus, elongation percentage at the break, and mechanical strength of PVA/PAA nanofibers improved with mBN loading. The thermal conductivity of composite nanofibers reached 0.12 W/m·K at mBN content of 1.0 wt% due to the continuous heat conduction pathways of mBN. In the meantime, while there was no cytotoxicity recorded for both L929 and HUVEC cell lines for all composite nanofibers, the antimicrobial efficiency improved with the incorporation of mBN compared with PVA/PAA and recorded as 68.8% and 75.1% for Escherichia coli and Staphylococcus aureus, respectively. On this basis, the present work proposes a promising biomaterial for biomedical applications such as dual drug delivery, particularly including both hydrophobic and hydrophilic drugs or wound dressing.
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