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    Chitosan and chitosan/turmeric-based membranes for wound healing: Production, characterization and application

    Year: 2023

    Journal: International Journal of Biological Macromolecules, Volume 253, 2023-12-31, page 127425

    Authors: Pacheco, Karoline M. L.; Torres, Bruno B. M.; Sanfelice, Rafaela C.; da Costa, Mardoqueu M.; Assis, Lívia; Marques, Rosemarie Brandim; Filho, Antônio Luiz Martins Maia; Tim, Carla R.; Pavinatto, Adriana

    Keywords: Biomaterials; Casting films; Skin lesions repair

    In the present study, chitosan and chitosan/turmeric-based membranes were produced, characterized and applied in in vivo experiments showing the applicability for skin wound repair. Chitosan 1 % (w/v), chitosan + glycerol 30 % (w/w) and chitosan + glycerol 30 % + turmeric 1.5 % (w/w) membranes were produced through the casting technique. Self-sustainable, homogeneous, and flexible membranes were obtained from all materials tested. The FTIR spectra showed the main vibrational bands for materials used in the chemical groups. The membranes containing glycerol are more flexible than those formed with pure chitosan. Membranes formed with glycerol and glycerol/turmeric are more hydrophilic compared to the membranes formed by pure chitosan. The in vivo results showed that the group who received the chi/gly/turmeric membrane had a statistically greater reduction in the injured area, as well as a better healing process in the histological analysis compared to the other experimental groups. The material developed here is from a natural source, low cost and easy to apply and can accelerate the process of repairing skin lesions.
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