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    Chromatic Dendrimer/Polydiacetylene Nanoparticles

    Year: 2021

    Journal: ACS Appl. Polym. Mater., Volume 3, JUN 11, page 2931–2937

    Authors: Israeli, Reut; Kolusheva, Sofiya; Mateos-Gil, Pablo; Gizeli, Electra; Jelinek, Raz

    Keywords: dendrimer; hyperbranched polymers; polydiacetylene; polymer nanoparticles; acoustic sensing; cell labeling

    Polydiacetylenes (PDAs) constitute a unique class of chromatic conjugated polymers, and their optical properties have been employed in diverse biological and chemical diagnostic applications. We constructed composite nanoparticles (NPs) comprising PDA and a dendritic amphiphilic polymer. The dendrimer/PDA NPs exhibit structural and chromatic stability and constitute an excellent platform for sensing and analysis of biomolecular membrane interactions, both in model vesicle systems and in a live-cell environment. Interestingly, the dendritic polymer shielded the PDA matrix and modulated its interactions with external stimuli such as heat and amphiphilic biomolecules. Furthermore, the dendrimer-layer-mediated association of the composite NPs with lipid bilayers in giant vesicles and live mammalian cells, thereby facilitating microscopic analysis of lipid bilayer interactions in actual membrane environments. The dendrimer/PDA NPs may serve as a broad-based vehicle for analysis of membrane interactions in diverse model and natural environments.
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