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    Composite Materials Based on Gelatin and Iron Oxide Nanoparticles for MRI Accuracy

    Year: 2022

    Journal: Materials, Volume 15, MAY

    Authors: Drobota, Mioara; Vlad, Stelian; Gradinaru, Luiza Madalina; Bargan, Alexandra; Radu, Iulian; Butnaru, Maria; Rimbu, Cristina Mihaela; Ciobanu, Romeo Cristian; Aflori, Magdalena

    Organizations: Project Partnerships for knowledge transfer in the field of polymer materials used in biomedical engineering [P_40_443, 86/8.09.2016, SMIS 105689]; European Regional Development Fund by the Competitiveness Operational Programme 2014-2020, Axis 1 Research, Technological Development and Innovation

    Keywords: gelatin; iron oxide; tensile properties; dynamic vapor sorption analysis; magnetic determination; antibacterial activity

    The majority of recent studies have focused on obtaining MRI materials for internal use. However, this study focuses on a straightforward method for preparing gelatin-based materials with iron oxide nanoparticles (G-Fe2O3 and G-Fe3O4) for external use. The newly obtained materials must be precisely tuned to match the requirements and usage situation because they will be in close touch with human/animal skin. The biocompatible structures formed by gelatin, tannic acid, and iron oxide nanoparticles were investigated by using FTIR spectroscopy, SEM-EDAX analysis, and contact angle methods. The physico-chemical properties were obtained by using mechanical investigations, dynamic vapor sorption analysis, and bulk magnetic determination. The size and shape of iron oxide nanoparticles dictates the magnetic behavior of the gelatin-based samples. The magnetization curves revealed a typical S-shaped superparamagnetic behavior which is evidence of improved MRI image accuracy. In addition, the MTT assay was used to demonstrate the non-toxicity of the samples, and the antibacterial test confirmed satisfactory findings for all G-based materials.
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