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    Designing and Evaluating pH-Responsive Electrospun Eudragit® L-100/Hydroxypropyl Methyl Cellulose Composite Mats for Release of Propolis as a Novel Wound Dressing

    Year: 2023

    Journal: Journal of Polymers and the Environment, Volume 31, 2023-07-01

    Authors: Abdi, Mahdieh; Zakeri-Milani, Parvin; Ghorbani, Marjan

    Keywords: Polymers; Wound dressing; Environmental Chemistry; Eudragit® L 100; Hydroxypropyl methyl cellulose; pH-sensitive; Propolis

    Alkaline pH levels in chronic wounds increase the risk of bacterial accumulation. Therefore, the pH value is a key factor in the wound healing process. In this regard, an attempt was made to introduce a new composite nanofiber for the treatment of chronic wounds. In this wound dressing, the composite of Eudragit® L-100 (EU), which dissolves only at pH above 6, and hydroxypropyl methyl cellulose (EU/HPMC) was used to load propolis (PRO), which has antibacterial and antioxidant properties. We investigated the morphological and physicochemical properties of this new pH-sensitive mat composed of different blending ratios of EU/HPMC/PRO. The scanning electron microscope (SEM) images exhibited that by increasing the propolis content in the range of 10–30% v/v, the average diameter of nanofibers increased from 589.82 ± 102.5 to 676.01 ± 127.3 nm. The results of Fourier transform infrared spectroscopy (FT-IR), thermal gravimetric analysis, mechanical properties, and water contact angle of mats confirmed the successful loading of PRO into the nanofibers. In addition, we evaluated the antibacterial properties of optimal mat against Staphylococcus aureus (Gram positive) and Escherichia coli (Gram negative) bacteria, cell proliferation, and cell adhesion. Finally, we compared the release rate of propolis from nanofibers in media at pH 7.4 and 5.5. The results showed that the EU/HPMC/PRO nanofibers had good potential to be used as a wound dressing.
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