Contact
    Start Publications Development and characterization of rapid dissolving ornidazole ...
    ←  Publication Finder
    Attension

    Development and characterization of rapid dissolving ornidazole loaded PVP electrospun fibers

    Year: 2019

    Journal: Pharm. Dev. Technol., Volume 24, AUG 9, page 864–873

    Authors: Tort, Serdar; Yildiz, Aysegul; Tugcu-Demiroz, Fatmanur; Akca, Gulcin; Kuzukiran, Ozgur; Acarturk, Fusun

    Keywords: Electrospinning; electrospun fibers; rapid dissolving; ornidazole; gingivitis

    Gingivitis is a common and mild form of periodontal disease and can be described as a limited inflammation of the gingiva. This study aims to develop and characterize rapid releasing mucoadhesive fibers containing ornidazole with electrospinning process for the treatment of gingivitis. Polyvinylpyrrolidone (PVP) was chosen as a polymer and used at different concentrations of 10%, 12.5%, and 15%. Scanning electron microscopy images showed that fiber diameters increased with increasing polymer concentrations. Tensile strength and elongation at break values of fibers increased with increasing PVP amount, whereas the loading of ornidazole into the fibers decreased these parameters. The contact angle values of all fibers were found to be 0 degrees due to the hydrophilic nature of PVP. Ornidazole was released within 5min and diffused from all of the fibers faster than that of gel and solution formulations. Electrospun ornidazole fibers were found efficient against Porphyromonas gingivalis in antimicrobial activity studies. The results demonstrated that ornidazole loaded fibers could be a potential drug delivery system for the treatment of gingivitis.
    View publication