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    Development of biocide coated polymers and their antimicrobial efficacy

    Year: 2023

    Journal: Nano Select, Volume 4, 2023-07

    Authors: Watson, Rowan; Maxwell, Maria; Dunn, Sophie; Brooks, Alexander; Jiang, Long; Hill, Harriet J.; Williams, Georgia; Kotowska, Anna; Nikoi, Naa Dei; Stamataki, Zania; Banzhaf, Manuel; Scurr, David; Bryant, Jack Alfred; de Cogan, Felicity

    Keywords: antibacterial; coating; antimicrobial; C7H4N2Cl–; chlorhexidine; surfaces

    Abstract Microbial contamination of plastic surfaces is a significant source of hospital-acquired infections. To produce antimicrobial surfaces, chlorhexidine was attached to nitrided acrylonitrile butadiene styrene (ABS). The uniformity of chlorhexidine distribution on the plastic surfaces was revealed by time-of-flight secondary ion mass spectrometry (TOF-SIMS) imaging. Its antimicrobial efficacy was established against model pathogenic Gram-positive and Gram-negative bacteria, fungi, and viruses. The stability of the bonded chlorhexidine was evaluated via a leaching test. The surfaces rapidly killed microbes: no viable colonies of Escherichia coli, Staphylococcus aureus, or Candida albicans were recoverable after 45 minutes. It was effective against SARS-COV-2, with no viable virions found after 30 minutes. Additionally, the surfaces were as effective in killing chlorhexidine-resistant strains of bacteria as they were in killing naïve strains. The surface was stable; after 2 weeks of leaching, no detectable chlorhexidine was found in the leachate. We believe that the technology is widely applicable to prevent the spread of fomite infection.
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